Endocrine Abstracts

It is generally believed that the signal transduction of AT1 angiotensin receptor (AT1R), the major receptor of angiotensin II, requires ligand binding and subsequent adoption of its active conformation. Activated AT1R induces a plethora of signaling pathways, in contrast to inactive AT1R, which was thought to be silent in terms of signaling. We hypothesized that unliganded, but phosphorylated AT1R may recruit β-arrestins, the key proteins of receptor desensitization, int...